Somatic Mosaicism and Disease
نویسندگان
چکیده
منابع مشابه
Somatic Mosaicism and Disease
The large number of cell divisions required to make a human body inevitably leads to the accumulation of somatic mutations. Such mutations cause individuals to be somatic mosaics. Recent advances in genomic technology now allow measurement of somatic diversity. Initial studies confirmed the expected high levels of somatic mutations within individuals. Going forward, the big questions concern th...
متن کاملHypothesis: Somatic Mosaicism and Parkinson Disease
Mutations causing genetic disorders can occur during mitotic cell division after fertilization, which is called somatic mutations. This leads to somatic mosaicism, where two or more genetically distinct cells are present in one individual. Somatic mutations are the most well studied in cancer where it plays an important role and also have been associated with some neurodegenerative disorders. T...
متن کاملLetter to the Editor: Hypothesis: Somatic Mosaicism and Parkinson Disease
We have read with great interest the review published in your journal titled “Hypothesis: Somatic Mosaicism and Parkinson Disease (Exp Neurobiol. 2014 Dec;23:271-276),” which discusses the “potential” existence of mosaicisms in Parkinson’s disease. We find it essential to clarify some concepts that we consider inadequate/incorrect because they are presented as a new hypothesis when in fact our ...
متن کاملSomatic and germline mosaicism in sporadic early-onset Alzheimer's disease.
Alzheimer's disease (AD) is the commonest neurodegenerative disease worldwide. Rare familial cases may be caused by mutations in one of three genes-amyloid precursor protein, presenilin-1 and presenilin-2; however, the molecular basis of >99% of AD cases is unknown. Somatic mutation has been considered to be a mechanism that may account for a proportion of sporadic cases of AD, but to date ther...
متن کاملSomatic Mosaicism in Blaschkolinear Inflammatory Disorders
Linear lichen planus (LP) is a rare dermatologic disease in which lichenoid lesions conform to a blaschkolinear distribution, most commonly on the extremities. Linear discoid lupus erythematosus (DLE) is a cutaneous manifestation of lupus that also conforms to Blaschko’s lines. Blaschkolinear disorders have been shown to result from somatic mosaicism, most recently in nevus sebaceus, epidermal ...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2014
ISSN: 0960-9822
DOI: 10.1016/j.cub.2014.05.021